Franklin offers dedicated clinical-grade reporting capabilities for multiple workflows, as described in detail in this link. This article aims to provide additional insights into the features that specifically support reporting when implementing virtual panels in larger tests such as Whole Exome Sequencing (WES), Whole Genome Sequencing (WGS), or extensive panels.
As mentioned in the article "Overview of Franklin Solution for Virtual Panels," Franklin utilizes two types of panels:
Hard Panels: These panels filter the analysis and do not allow the end user to modify or change them during the analysis process.
Soft Panels: These panels can be added or removed during the analysis based on the findings.
When generating reports, Franklin automates the inclusion of details according to the panels applied at the time of report sign-off. The following sections are automatically adjusted:
Test Details: The panel selection can modify the report title, test description, and other relevant details.
List of Analyzed Genes: The selected panels determine the list of genes tested, which is presented in the report. It's important to note that if both a hard panel and a soft panel are applied, the genes from the soft panel will be displayed. This functionality is designed to support scenarios where the hard panel encompasses a broader gene list, while the soft panel focuses on a narrower subset. For example, if a hard panel for "Comprehensive Arrhythmia and Cardiomyopathy" consisting of 150 genes is applied, along with a soft panel for "Long QT Syndrome" encompassing 13 genes, the "List of Analyzed Genes" section will only display the 13 genes from the "Long QT" panel if it is applied during case sign-off.
Report - Gene Analyzed List
Regions of Limited or Inadequate Coverage: This section is particularly crucial for panels reporting, as it ensures comprehensive coverage of the entire panel based on the selected threshold. It highlights regions with limited coverage within the genes of the selected panel. The level of region resolution, whether genes, exons, or regions, can be adjusted according to the reporting configuration.
By leveraging Franklin's robust reporting capabilities, users can effectively communicate the outcomes of virtual panel analyses, capturing the relevant details and ensuring comprehensive coverage of the selected panel genes.
Still have questions? Reach out to our Support Team, they'll be happy to help!