Automated reanalysis is a powerful feature in Franklin. With the monthly update of the latest evidence and guidelines, Franklin ensures that variants and cases are continuously monitored for potential reclassification.

There are two options for conducting automated reanalysis in Franklin Community: "Follow Variant" and "Follow Case." These features allow you to receive notifications and updates when new evidence emerges, enabling you to stay informed and make well-informed decisions regarding variant interpretation.

"Follow Variant" is an automated reanalysis option in Franklin that sends you an email notification whenever there is new evidence for a specific variant that may lead to reclassification, following the guidelines provided by the American College of Medical Genetics and Genomics (ACMG). This feature helps you stay informed about the latest developments associated with specific variants of interest.

Here's how to utilize the "Follow Variant" option:

Log in to your Franklin account and navigate to the main website.

Identify the variant you wish to monitor for potential reclassification. It could be a variant present in one of your cases or a variant of general interest.

Pro tip: you can check out the "Examples" window to verify the different nomenclatures supported by Franklin's search engine for SNPs, CNVs, and ROHs.

On the Variant Interpretation hub, right next to the "Classift Variant" button, you will find an option to "Follow". Click on this button to activate the automated reanalysis for that particular variant.

From this point forward, Franklin will monitor the variant and inform you via email whenever there are new pieces of evidence available on the variant, gene, and associated conditions levels, or guideline changes that could impact the variant's ACMG classification.

The "Follow Case" feature in Franklin automatically tracks and reanalyzes all the variants within the Workbench of a specific case. These variants were either prioritized by Franklin's AI-driven engine automatically, or you can manually add them to the workbench by selecting them from the Variants tab.

This can be useful when you want to stay updated on multiple variants simultaneously, for example, for all variants with a VUS classification in unsolved cases.

Here's how to use the "Follow Case" option:

Go to the "My Cases" tab and open the case that contains the variants you want to monitor.

Check that all the variants that you're interested in getting automated updates are displayed in the "Analysis Results" section.

Franklin's AI-driven engine might have already prioritized some variants as potentially causal.

You can manually add variants to the workbench by navigating to the Variants tab. Once you have chosen the candidate variant for reanalysis, click on the three dots on the right-hand side edge of the tile, and select "Add to Workbench".

Once you have finalized the list of variants to be monitored, select the "Follow Case" option. This action initiates automated reanalysis for all the variants within the Workbench.

Franklin will automatically monitor and reanalyze the variants within the Workbench of the case, providing you with email notifications whenever new evidence or guideline changes may affect their classification.

Pro tip: Franklin Professional also has an automated Whole Reanalysis tool to re-annotate and update the classification of all the variants in a case. Reach out to us to learn more about this capability.

To sum up, automated reanalysis is a valuable feature of Franklin, empowering users to stay informed about emerging evidence and guideline updates in genetic analysis and reinterpretation. By utilizing the "Follow Variant" and "Follow Case" options, you can efficiently monitor specific variants or cases for potential reclassification.

These features ensure that you are always up-to-date with the latest developments, enabling you to make well-informed decisions based on the most current and accurate information available.
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