Franklin provides a solution for the interpretation of both somatic and germline variants.

In order to search for a somatic variant and explore Franklin somatic data,

switch the toggle in Franklin's homepage to the "Somatic" mode.

After typing the variant in the search line, add your specific case details by answering the guiding questions. Providing the patient cancer type is especially important since it will impact directly on Franklin's AMP tier-based classification.

The search button will open the Variant Exploration Hub where you can find the variant somatic data alongside all Franklin's germline interpretation tools.

Under the Somatic Clinical Evidence tab, you will find the variant classification, according to AMP guidelines.

Below the classification, Franklin provides a list of therapeutic, diagnostic, prognostic, and predisposing evidences from multiple sources such as:

-FDA approved drugs

-NCCN guidelines

-Civic

-Clinicaltrails.org

-Literature curation

All of the pieces of evidence are shown with their level calculated based on the evidence data and the specific case cancer type. The evidence scope is ranging from 'gene-level scope' to 'variant-level scope' meaning the evidence is specific to the searched variant.

Under the 'Clinical trails' tab, you will find a list of all relevant clinical trials. This list can be filtered by phase, location, status, and date.

Additional somatic annotations like Cosmic frequency can be found In the Variant Assessment tab.

Franklin Variant Exploration Hub offers additional germline variant information including Genoox ACMG Classification and Publications