Franklin applies specific color schemes across variant classification workflows to support rapid assessment of clinical significance.
Germline Variant Classification
Color coding is applied across the Franklin ACMG Classification presentation, the Variants tab, and variant tiles within the Workbench to indicate the clinical significance of each variant. The standardized color scheme is as follows:
Pathogenic (P): Red
Likely Pathogenic (LP): Orange
Variant of Uncertain Significance (VUS): Gray
Likely Benign (LB): Blue
Benign (B): Green
Somatic Variant Classification
This color coding is displayed in the Variant Interpretation Hub under Somatic Clinical Evidence, as well as in the Variants Tab and Case Summary, to indicate the clinical significance of somatic variants based on AMP tiers:
Tier I (Strong clinical significance): Red
Tier II (Potential clinical significance): Orange
Tier III (Unknown clinical significance): Gray
Tier IV (Benign or Likely Benign): Green
Variants without classification: Transparent
Oncogenic Classification
This color scheme is primarily used in research and cancer-focused workflows to represent oncogenic potential:
Oncogenic: Red
Likely Oncogenic: Orange
Variant of Uncertain Significance (VUS): Gray
Likely Benign: Blue
Benign: Turquoise
False: Black
The color coding described above also applies to My Organization classifications and is integrated into both the ClinVar and Somatic Evidence tiles.
See for example Workbench’s variant tiles > Germline ClinVar information: