Version 83.4 Update

We are happy to introduce several enhancements and new features in our latest update:

In tumor (somatic) cases, the variant’s Somatic Clinical Evidence tab has been enhanced in terms of functionality and layout. Reminder: this tab allows you to view Franklin-suggested therapeutic, diagnostic, and prognostic evidence - and add your own. You can find more details on somatic clinical evidence on Franklin Help Center, here.

Evidence added by users on the organization (organization evidence) now show the "My Org" label on the list of evidence presented on the variant’s Somatic Clinical Evidence tab:
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The "My Org" label is also shown on drug tiles on the Case Summary tab of the workbench:
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The enhanced “Add Evidence” pop-up (available for SNP variants) now shows separated tabs for therapeutic, diagnostic, and prognostic evidence, and the additional evidence details are shown in a dedicated expandable section:
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Notes:
-Organization evidence added for a variant in the current case will appear on the Somatic Clinical Evidence tab in all past and future cases that contain the variant.
-If an organization evidence is added for a variant after the variant was added to the report, the newly added evidence will not be automatically reflected in the Case Summary tab and the report. To introduce the newly added evidence into Case Summary and the report, the variant needs to be removed from, then added back to, the report.
-Organization evidence continues to have no effect on the somatic classification as calculated by Franklin.
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Various exome and panel kits provide oligonucleotide probes for enhanced backbone capture. The probes facilitate CNV detection by ensuring uniform coverage of intronic and intergenic regions. Franklin now supports viewing the backbone for CNV assessment by opening the case in desktop IGV, with tracks that show coverage, predicted copy number, and allele balance. This option is available for relevant assays from the case context menu, via the option "Open case in desktop IGV". To gain access to this ability, please contact our support team at [email protected], specifying the assay you would like to enable this for.

Fixed an issue where quick filters that utilize a “Compare With” filter, which references a deleted case for comparison, has prevented the annotation of new cases that use the quick filter.