# Franklin Help Center

> How can we help you?

## About Franklin

- [Contact Us](http://help.genoox.com/en/articles/7863873-contact-us.md): Connect with Franklin by QIAGEN for support, advanced support for premium users, and training and platform upgrades.
- [Who was Franklin?](http://help.genoox.com/en/articles/8042182-who-was-franklin.md): Learn about Rosalind Franklin, the Inspiration behind Franklin, and why we chose to name our platform after this inspiring scientist
- [Franklin Premium Features Overview](http://help.genoox.com/en/articles/10053759-franklin-premium-features-overview.md): Franklin delivers an end-to-end solution from raw data to report generation, with powerful, adaptable features to optimize lab workflows
- [Symbol Glossary](http://help.genoox.com/en/articles/11745509-symbol-glossary.md)
- [Troubleshooting](http://help.genoox.com/en/articles/11745277-troubleshooting.md)
- [Introduction to Franklin](http://help.genoox.com/en/articles/11748053-introduction-to-franklin.md)
- [Glossary of Terms and Abbreviations](http://help.genoox.com/en/articles/11814486-glossary-of-terms-and-abbreviations.md)
- [Security-Relevant Warnings and Information](http://help.genoox.com/en/articles/11822462-security-relevant-warnings-and-information.md)
- [Technical and Procedural Security and Privacy Safeguards](http://help.genoox.com/en/articles/11823254-technical-and-procedural-security-and-privacy-safeguards.md)
- [Analytical and Clinical Performance Characteristics](http://help.genoox.com/en/articles/14656043-analytical-and-clinical-performance-characteristics.md)
- [Expected Erroneous Results for Analytical and Clinical Validations](http://help.genoox.com/en/articles/14656204-expected-erroneous-results-for-analytical-and-clinical-validations.md)
- [Franklin Support - Free Users](http://help.genoox.com/en/articles/12616576-franklin-support-free-users.md): This article outlines the scope of support available to Franklin’s free users.
- [Minimum Secure Operating Environment](http://help.genoox.com/en/articles/14679000-minimum-secure-operating-environment.md)
- [Network and Connectivity Guidance](http://help.genoox.com/en/articles/14679459-network-and-connectivity-guidance.md)
- [Product Label - Franklin by QIAGEN](http://help.genoox.com/en/articles/13509695-product-label-franklin-by-qiagen.md)

## How to start using Franklin

- [Access Control and Authentication](http://help.genoox.com/en/articles/11745133-access-control-and-authentication.md)
- [How Franklin is Organized](http://help.genoox.com/en/articles/4238242-how-franklin-is-organized.md)
- [Registration Requirement in Franklin](http://help.genoox.com/en/articles/12638123-registration-requirement-in-franklin.md): Learn why Franklin now requires user registration and how this change improves your experience — while keeping the platform free.

## Franklin's My Cases

- [10 Case Upload Limit in Franklin Community](http://help.genoox.com/en/articles/14315180-10-case-upload-limit-in-franklin-community.md): Starting April 15, 2026, Franklin's free tier includes up to 10 cases per month.

## Case Analysis 

- [Franklin best practices for case investigation](http://help.genoox.com/en/articles/4177761-franklin-best-practices-for-case-investigation.md): how to analyse your first genetic case using Franklin
- [Working in the Workbench](http://help.genoox.com/en/articles/4277712-working-in-the-workbench.md): Learn about the information shown in the Workbench, the main view of any case in Franklin, and how to leverage its insights
- [Franklin's AI-based variant prioritization engine](http://help.genoox.com/en/articles/4444301-franklin-s-ai-based-variant-prioritization-engine.md): Learn more about Franklin's artificial intelligence-driven algorithms to pinpoint the relevant variants in case analysis.
- [UPD detection in Franklin](http://help.genoox.com/en/articles/7056497-upd-detection-in-franklin.md): Franklin supports UPD detection in trio analysis
- [Collaborating with Your Team in Franklin](http://help.genoox.com/en/articles/7220878-collaborating-with-your-team-in-franklin.md): Collaborate with your team in Franklin for streamlined genetic analysis using features like comments, evidence, and workload management.
- [Including Variants in the Report](http://help.genoox.com/en/articles/8076312-including-variants-in-the-report.md): Learn how to categorize variants into different reporting bins, in order to include them in the report
- [Conducting Automated Reanalysis in Franklin](http://help.genoox.com/en/articles/8116651-conducting-automated-reanalysis-in-franklin.md): A guide to Franklin's embedded automated reanalysis features - "Follow variant" and "Follow case".
- [Case Protocols](http://help.genoox.com/en/articles/8362725-case-protocols.md): Franklin's Protocols allows you to better track and manage the progress of a cases in your organization
- ["Family Carrier Test" on Trio Cases](http://help.genoox.com/en/articles/8742207-family-carrier-test-on-trio-cases.md): Trio Cases include a "Family Carrier Test" that examines variants present in both parents.
- [Variant Confidence](http://help.genoox.com/en/articles/4341427-variant-confidence.md): Confidence calculation for SNPs, Indels, CNVs and Fusions
- [CNV calling QC metrics](http://help.genoox.com/en/articles/7041472-cnv-calling-qc-metrics.md): CNV calling QC metrics aim to measure coverage distribution fit to reference samples distribution
- [Consanguinity and Relatedness check](http://help.genoox.com/en/articles/6763006-consanguinity-and-relatedness-check.md): Relatedness, consanguinity, and paternity tests in a family analysis
- [Franklin Confidence for Dragen 4.X](http://help.genoox.com/en/articles/9910173-franklin-confidence-for-dragen-4-x.md): This document explains the parameters used to determine the confidence value for variants in the Dragen 4.X pipeline
- [Understanding QC Metrics in Franklin](http://help.genoox.com/en/articles/12645109-understanding-qc-metrics-in-franklin.md): Quality control \(QC\) metrics are essential for ensuring the accuracy and reliability of genomic data analyzed in Franklin. This article provides an overview of the QC parameters available in Franklin.
- [Franklin's Advanced Filtering System](http://help.genoox.com/en/articles/7211900-franklin-s-advanced-filtering-system.md): Optimize sample analysis with Franklin's advanced filters. Our guide offers effective explanations and guidance for using all filters.
- [Creating and Managing Quick Filter Presets for Variant Triage in Franklin](http://help.genoox.com/en/articles/7212060-creating-and-managing-quick-filter-presets-for-variant-triage-in-franklin.md): Learn how to easily create and manage quick filter presets for your laboratory's variant triage process.
- [Merged Filters](http://help.genoox.com/en/articles/7173418-merged-filters.md): Combine multiple quick filters into one powerful preset to streamline variant review.
- [HGMD in Franklin](http://help.genoox.com/en/articles/12569603-hgmd-in-franklin.md)

## Franklin Variant Interpretation Hub

- [Variant associated conditions overview](http://help.genoox.com/en/articles/4307549-variant-associated-conditions-overview.md): Meet Franklin powerful Geno-Pheno engine that collects and curated data from multiple sources to help you find the relevant condition
- [Franklin's Publication engine](http://help.genoox.com/en/articles/4238268-franklin-s-publication-engine.md): Explore Franklin's rich and comprehensive genomic literature database for SNP and CNV interpretation
- [Variant Community Feed](http://help.genoox.com/en/articles/4362898-variant-community-feed.md): Discover new evidence shared by Franklin community members

## Franklin's Knowledge Base

- [Building your Knowledge Base](http://help.genoox.com/en/articles/6502423-building-your-knowledge-base.md): Learn how to build up your organization's curated repository, and leverage past classifications and other insights in future cases.
- [Virtual Panels](http://help.genoox.com/en/articles/4350427-virtual-panels.md): Create and manage Gene panels with Franklin, to streamline the case analysis process
- [Uploading a genes file to a panel](http://help.genoox.com/en/articles/5890707-uploading-a-genes-file-to-a-panel.md): Walk through our file format and explain all you need to know in order to upload a list of genes to a panel.
- [Importing variants to your Knowledge Base](http://help.genoox.com/en/articles/6531946-importing-variants-to-your-knowledge-base.md): Franklin allows the integration of your historical variant repository into the platform, providing insights from past classifications.
- [Panel Editing and Versioning](http://help.genoox.com/en/articles/8825142-panel-editing-and-versioning.md): Learn how to effortlessly manage and update gene panels in Franklin with our Panel Versioning feature
- [My Organization Classification](http://help.genoox.com/en/articles/11822738-my-organization-classification.md)
- [Variant Classification Interface: Guided ACMG Classification](http://help.genoox.com/en/articles/14688107-variant-classification-interface-guided-acmg-classification.md)

## Managing My Organization

- [Inviting a new teammate to your organization](http://help.genoox.com/en/articles/4838573-inviting-a-new-teammate-to-your-organization.md): How to manage your organization members
- [Configuring User and Organizational Roles and Permissions](http://help.genoox.com/en/articles/7228888-configuring-user-and-organizational-roles-and-permissions.md)
- [Franklin's Credit Report Dashboard](http://help.genoox.com/en/articles/7965820-franklin-s-credit-report-dashboard.md): Gain valuable insights into credit consumption, track credits, manage samples, and plan strategically for the future.
- [Viewing and Editing Assays in Franklin](http://help.genoox.com/en/articles/14455863-viewing-and-editing-assays-in-franklin.md)

## Franklin Secondary Analysis

- [CNV detection by Franklin](http://help.genoox.com/en/articles/5365431-cnv-detection-by-franklin.md): An introduction to Rainbow - Franklin’s advanced CNV detection
- [Rainbow CNV model requirements](http://help.genoox.com/en/articles/15916624-rainbow-cnv-model-requirements.md)
- [Understanding CNV Model Performance Reports](http://help.genoox.com/en/articles/15916639-understanding-cnv-model-performance-reports.md)

## Franklin ACMG Automated Classification

- [Gene missense sensitivity rules - PP2, BP1](http://help.genoox.com/en/articles/4384106-gene-missense-sensitivity-rules-pp2-bp1.md)
- [Prediction tools PP3, BP4](http://help.genoox.com/en/articles/6240723-prediction-tools-pp3-bp4.md)
- [Frequency rules - PM2, BS1, BS2, BA1](http://help.genoox.com/en/articles/6881015-frequency-rules-pm2-bs1-bs2-ba1.md)
- [Reported variants rules - PP5, BP6, PS1, PM5](http://help.genoox.com/en/articles/4230472-reported-variants-rules-pp5-bp6-ps1-pm5.md): The following rules PP5, BP6, PS1, PM5 rules are based on evidence coming from known classified variants
- [Loss of function rule - PVS1](http://help.genoox.com/en/articles/4230109-loss-of-function-rule-pvs1.md): Here you can find more details about Franklin's implementation of the ACMG PVS1 rule used for SNP variants classification
- [Hotspot rule - PM1](http://help.genoox.com/en/articles/4230441-hotspot-rule-pm1.md): Here you can find more details about Franklin's implementation of the ACMG PM1 rule used for SNP variants classification
- [Franklin ACMG/ClinGen CNV classification](http://help.genoox.com/en/articles/7887793-franklin-acmg-clingen-cnv-classification.md)

## Franklin for Oncology

- [Franklin Somatic Variant Interpretation](http://help.genoox.com/en/articles/4996685-franklin-somatic-variant-interpretation.md)

## Franklin for Whole Genome Analysis

- [Whole Genome Viewer](http://help.genoox.com/en/articles/7223119-whole-genome-viewer.md)

## Franklin for Virtual Panels

- [Franklin Virtual Panel Solution Overview](http://help.genoox.com/en/articles/7877017-franklin-virtual-panel-solution-overview.md): An overview of Franklin's dedicated solution for applying virual panles
- [Hard Panels](http://help.genoox.com/en/articles/7178079-hard-panels.md)
- [Virtual panels Quality Control metrics](http://help.genoox.com/en/articles/7956371-virtual-panels-quality-control-metrics.md): Explanation on key QC metrics relevant to the virtual panels workflow
- [Virtual Panels Reporting](http://help.genoox.com/en/articles/7958219-virtual-panels-reporting.md): This article provides insight on specific features design to support reporting of virtual panel cases

## Franklin for Microarray

- [Video tutorial for CytoScan analysis in Franklin](http://help.genoox.com/en/articles/6503232-video-tutorial-for-cytoscan-analysis-in-franklin.md): Check out this short tutorial to learn how to import and analyze ChAS samples in Franklin, including segment classification and reporting
- [Creating your first microarray case in Franklin](http://help.genoox.com/en/articles/6498478-creating-your-first-microarray-case-in-franklin.md): Discover how to import cytogenetic cases into Franklin

## Franklin Global Community

- [Franklin Community Sharing Policy](http://help.genoox.com/en/articles/4252243-franklin-community-sharing-policy.md): Learn more about what data is shared with Franklin community

## FAQ

- [Create a case from a VCF - troubleshooting for files with \>10M variant rows](http://help.genoox.com/en/articles/6548243-create-a-case-from-a-vcf-troubleshooting-for-files-with-10m-variant-rows.md)
- [Manually adding or editing variants in a case](http://help.genoox.com/en/articles/6639095-manually-adding-or-editing-variants-in-a-case.md): This article describes the process of adding new variants to a case analysis or editing existing called variants, for both SNV's and CNV's
- [Resolving Performance and Family Creation Issues on Franklin](http://help.genoox.com/en/articles/9728540-resolving-performance-and-family-creation-issues-on-franklin.md)

## Franklin Updates

- [Big News: Franklin Is Joining Forces with QIAGEN!](http://help.genoox.com/en/articles/11369578-big-news-franklin-is-joining-forces-with-qiagen.md): Franklin is officially joining the QIAGEN family — a global leader in molecular diagnostics and bioinformatics.

## Videos

- [Watch Franklin Exclusive Webinars](http://help.genoox.com/en/articles/9413116-watch-franklin-exclusive-webinars.md): Watch Franklin's previously streamed webinars on a variety of topics related to genomics and their practical usage on the Franklin platform.
- [Variant Interpretation Video Tutorial](http://help.genoox.com/en/articles/4548752-variant-interpretation-video-tutorial.md): Upgrading you variant search to a clinical case, Selecting Variant Clinical Significance and more

## Franklin Color Coding

- [Classification Color coding](http://help.genoox.com/en/articles/11764921-classification-color-coding.md)
- [Evidence Levels Color Coding](http://help.genoox.com/en/articles/11821860-evidence-levels-color-coding.md)
- [Coverage Reports Color Coding](http://help.genoox.com/en/articles/11822025-coverage-reports-color-coding.md)
- [Regulatory Region Annotations Color Coding](http://help.genoox.com/en/articles/11822060-regulatory-region-annotations-color-coding.md)
- [Case Resolution Status Indicators](http://help.genoox.com/en/articles/11821957-case-resolution-status-indicators.md)