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Franklin ACMG Automated Classification
Read more about Franklin’s ACMG Classification engine
Gene missense sensitivity rules - PP2, BP1
Prediction tools PP3, BP4
Frequency rules - PM2, BS1, BS2, BA1
Reported variants rules - PP5, BP6, PS1, PM5The following rules PP5, BP6, PS1, PM5 rules are based on evidence coming from known classified variants
Loss of function rule - PVS1Here you can find more details about Franklin's implementation of the ACMG PVS1 rule used for SNP variants classification
Hotspot rule - PM1Here you can find more details about Franklin's implementation of the ACMG PM1 rule used for SNP variants classification
Franklin ACMG/ClinGen CNV classification