We are happy to introduce several enhancements and new features in our latest update:
Required Registration for Franklin
To enhance personalization and communication with our free-plan users, we are rolling out a registration requirement to Franklin. Moving forward, after a limited number of searches, users will be prompted to register. Once registration is complete, users can continue using Franklin freely - all features remain free of charge.
For more information on this matter, please visit the relevant Help Center article.
UPD Classification
You can now add a classification to a UPD biomarker. The UPD tile will now display your classification when available, and will continue to display Franklin’s classification as before.
Similar to variant classification, a classification is added using a dedicated popup opened from the tile’s classification icon. Interpretation notes and references can be entered in the popup, which always shows the most recent classification. When a UPD is added to the report, your classification of the biomarker will accordingly propagate to the report.
UPD As a Default Biomarker in Germline Cases
The UPD biomarker is now considered a default biomarker in germline cases - it will always appear in the case when detected, even if the assay configuration does not explicitly include it. Hence, Family cases in Franklin will now include the UPD biomarker by default, even if only other biomarkers (e.g. SMN or GBA) were configured in the assay. Presently, only UPD is considered a default germline biomarker. If you do not wish to include the default biomarkers (presently UPD) in your assay, please contact our support team ([email protected]).
Inheritance Model Added in Franklin Community Frequency
We have enhanced the Franklin Community Frequency widget by adding per-case inheritance information. When available, the widget’s community case tile now displays the Family Inheritance Status (e.g., Autosomal Dominant, Autosomal Recessive, De Novo, etc.) alongside existing per-case fields such and zygosity and confidence:
Note that this field appears only when inheritance data is present for the community case.
Tumor Cases: Hard Panel Support for SV
In tumor (somatic) cases, hard panels can now be applied to SVs (except for fusions). Hence, it is now possible to apply hard and soft panels to both SNP and SV in somatic cases, similar to germline cases. For more information on hard panels in Franklin, please visit the relevant Help Center article.
Bug Fixes
Tumor Cases: Clinical Trials List Automatically Matches Cancer Type
In tumor (somatic) cases, resolved an issue where the list of clinical trials under the Clinical Trials tab did not automatically filter by the patient’s cancer type. You can remove this default filter anytime if needed.
Tumor Cases: Fusion Exon Display in Closed Tiles
In tumor (somatic) cases, resolved an issue where the exon number for a fusion event was not consistently displayed between open and closed tiles. Now, the exon information shown in both tile states is aligned, providing accurate and consistent data for your variant analysis.